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Direct head-to-head data against tirzepatide showed CagriSema underperforming the highest tirzepatide dose at 84 weeks — meaning monotherapy claims of comparable efficacy are not supported by current Phase 3 evidence
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Dose Tmax Cmax AUClast Group Formulation Dosing route F, (%) (mg/Kg) (hr) (ng/mL) (ng.hr/mL) 8 mg/mL SEQ ID NO:3, PBS, lOmg/ mL, Sodium 1 0.74 PO gavage 4 7.1 228.3 0.19 Chenodeoxycholate, 2mg/mL Sodium Caprate, pH 8.0 8 mg/mL SEQ ID NO:3, PBS, PO IntelliCap ® lOmg/mL Sodium capsule - 2 0.74 0.5 60.7 1390.5 1.14 Chenodeoxycholate, proximal small 2mg/mL Sodium bowel Caprate, pH 8.0 8 mg/mL SEQ ID NO:3, PBS, lOmg/mL Sodium PO IntelliCap ® 3 0.74 0.25 386.0 4836.2 3.95 Chenodeoxycholate, proximal colon 2mg/mL Sodium Caprate, pH 8.0 0.1 mg/mL SEQ ID 4 0.01 IV 0.50 140.00 1654.72 100 NO:3 in PBS, pH 8.0 0.1 mg/mL SEQ ID 5 0.01 SC 24 45.1 1751.4 105.84 NO:3 in PBS, pH 8.0 [0323] This study utilizing the IntelliCap ® dosing capsule revealed the highest SEQ ID NO: 3 peptide absorption in the proximal colon, followed by the proximal small bowel regions of the GI tract in canines
